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    Association details:
    Biomarker:XPC K939G
    Cancer:Chronic Myeloid Leukemia
    Drug:imatinib (YD312) (c-KIT inhibitor, SCF signal transduction pathway inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    J Gene Med
    Title:

    Association of DNA repair gene XPC Ala499Val (rs2228000 C>T) and Lys939Gln (rs2228001 A>C) polymorphisms with the risk of Chronic Myeloid Leukemia: A case-control study in South Indian Population

    Published date:
    04/08/2021
    Excerpt:
    XPC Lys939Gln was found to correlate with poor response to therapy, showed borderline significant association with minor cytogenetic response (p= 0.08), and poor molecular response (p= 0.06).
    DOI:
    10.1002/jgm.3339