^
Association details:
| Biomarker: | XPA expression |
|---|---|
| Cancer: | Germ Cell Tumors |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
Excerpt:
...GCT patients with low XPA expression had significantly better overall survival than patients with high expression (hazard ratio = 0.38, 95% confidence interval: 0.12-1.23, p = 0.0228)...a correlation between inadequate or aberrant CDDP response and XPA expression found in GCT patients was also seen in GCT cell lines...
Secondary therapy:
Chemotherapy
DOI:
10.1186/s12885-019-6496-1
