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Association details:
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Source:
Title:

ASSOCIATION OF WILMS TUMOR GENE 1 EXPRESSION WITH OVERALL SURVIVAL AFTER AZACYTIDINE AND DONOR LYMPHOCYTE INFUSIONS: A RETROSPECTIVE SINGLE CENTER ANALYSIS

Published date:
05/11/2023
Excerpt:
Bone marrow Wilms tumor gene 1 expression (WT1), determined by RT-PCR….Patients (n=14) with a WT1 value of >150 at transplant had a significantly shorter median OS (5.3months; 95% CI 3.2-9.5) than patients (n=15) with WT1 ≤150 copies (13.5 months, 95% CI 2.0-18.1)....A Cox regression model with stepwise selection for potential predictors confirmed the statistically independent association between WT1 and OS after AZA±DLI, p=0.02....The present results indicate that WT1 levels at transplant and at relapse may be associated with overall survival after AZA±DLI in post-transplant relapse of MDS and AML.