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Association details:
| Biomarker: | VEGFC elevation |
|---|---|
| Cancer: | Gastroesophageal Cancer |
| Drug: | Sutent (sunitinib) (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A phase II and pharmacodynamic study of sunitinib in relapsed/refractory oesophageal and gastro-oesophageal cancers
Published date:
07/14/2015
Excerpt:
Patients who had clinical benefit had higher VEGF-C baseline values (P=0.04)....Sunitinib is well tolerated but only a select subgroup of patients benefited. Serum VEGF-A and -C may be early predictors of benefit.
DOI:
10.1038/bjc.2015.197
