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Association details:
| Biomarker: | USP18 overexpression |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | paclitaxel (Tubulin inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
USP18 reduces paclitaxol sensitivity of triple-negative breast cancer via autophagy
Published date:
02/19/2022
Excerpt:
In this study, differential expressed genes (DEGs) between TNBC cells and paclitaxol-resistant (taxol-R) TNBC cells were screened by bioinformatics analysis. Among these DEGs, USP18 mRNA expression was significantly increased in taxol-R TNBC cells. USP18 overexpression reduced paclitaxol sensitivity by decreasing paclitaxol-induced apoptosis and cell cycle arrest in TNBC cells.
DOI:
https://doi.org/10.1016/j.bbrc.2022.02.048