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    Association details:
    Biomarker:UPP1 overexpression
    Cancer:Lung Adenocarcinoma
    Drug:bosutinib (Bcr-abl inhibitor, Src kinase inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    IASLC-WCLC 2023
    Title:

    Characterization of the Immunosuppressive Function of UPP1high Tumor Cells in Lung Adenocarcinoma and Its Association with Immunotherapy

    Published date:
    08/08/2023
    Excerpt:
    In addition, using patient-derived organoids (PDOs), UPP1high LUAD patients were found to be more sensitive to Bosutinib and Dasatinib.