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Association details:
| Biomarker: | UGT1A1 rs1113193 |
|---|---|
| Cancer: | Colorectal Cancer |
| Regimen: | FOLFIRI (irinotecan + leucovorin calcium + 5-fluorouracil) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients
Excerpt:
The association of 285 haplotype-tagging SNPs in 11 candidate genes and overall survival (OS) was tested in two cohorts totalizing 417 FOLFIRI-treated mCRC…ABCC1 rs17501011G>A (HR = 2.08) and UGT1 rs1113193G>A (HR = 2.12) were associated with shorter OS (p ≤ 0.005)...ABCC1 tumor expression was associated with shorter survival (p ≤ 0.013).
DOI:
10.2217/pgs-2019-0091
