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Association details:
| Biomarker: | TYMS underexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Regimen: | FOLFIRI (5-fluorouracil + irinotecan + leucovorin calcium) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
MYC as a candidate upstream controller involved in TYMS gene expression and 5-FU/folate treatment efficacy in colorectal cancer
Published date:
05/19/2021
Excerpt:
In TCGA subjects suffering from colorectal cancer (CRC) (stage IV tumors, treated with FOLFOX/FOLFIRI (n = 38)), lower TYMS expression was associated with a better overall survival (OS).
DOI:
10.1200/JCO.2021.39.15_suppl.e15512
