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Association details:
| Biomarker: | TYMS underexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Modufolin (arfolitixorin) (Thymidylate synthase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Folate pathway gene expression in metastatic colorectal cancer patients treated with arfolitixorin/5-FU-based chemotherapy.
Published date:
01/11/2021
Excerpt:
Eighty-one (77.1%) of 105 patients provided material for this analysis. A lower pre-treatment expression of TYMS was associated with clinical benefit (PR and SD; p = 0.021).
Secondary therapy:
5-fluorouracil + irinotecan; 5-fluorouracil + oxaliplatin; 5-fluorouracil
Trial ID:
