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Association details:
Biomarker:TYMS underexpression
Cancer:Colorectal Cancer
Regimen:FOLFIRI (irinotecan + leucovorin calcium + 5-fluorouracil)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

MYC as a candidate upstream controller involved in TYMS gene expression and 5-FU/folate treatment efficacy in colorectal cancer

Published date:
05/19/2021
Excerpt:
In TCGA subjects suffering from colorectal cancer (CRC) (stage IV tumors, treated with FOLFOX/FOLFIRI (n = 38)), lower TYMS expression was associated with a better overall survival (OS).
DOI:
10.1200/JCO.2021.39.15_suppl.e15512