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Association details:
| Biomarker: | TTC39B rs72700653 |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | carboplatin (Tubulin polymerization promoter) + paclitaxel (Tubulin inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer
Published date:
01/31/2016
Excerpt:
To identify germline single-nucleotide polymorphisms (SNPs) that contribute to variations in individual responses to chemotherapy, we carried out a multi-phase genome-wide association study (GWAS) in 1,244 women diagnosed with serous EOC who were treated with the same first-line chemotherapy, carboplatin and paclitaxel. We identified two SNPs (rs7874043 and rs72700653) in TTC39B (best P=7x10-5, HR=1.90, for rs7874043) associated with progression-free survival (PFS).
DOI:
10.18632/oncotarget.7047