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Association details:
| Biomarker: | TPBG underexpression |
|---|---|
| Cancer: | Lung Cancer |
| Drug: | ASN004 (Microtubule inhibitor, 5T4-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ASN004, A 5T4-targeting scFv-Fc Antibody–Drug Conjugate with High Drug-to-Antibody Ratio, Induces Complete and Durable Tumor Regressions in Preclinical Models
Excerpt:
ASN004 was further evaluated in a tumor xenograft model derived from the H1975 human lung carcinoma cell line, which shows low expression of 5T4...Complete or near-complete tumor growth regression was observed for all dose groups by day 20, with similar tumor regression curves and no apparent dose response.
DOI:
https://doi.org/10.1158/1535-7163.MCT-20-0565
