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Association details:
| Biomarker: | TPBG underexpression + HER-2 overexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | ASN004 (Microtubule inhibitor, 5T4-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ASN004, A 5T4-targeting scFv-Fc Antibody–Drug Conjugate with High Drug-to-Antibody Ratio, Induces Complete and Durable Tumor Regressions in Preclinical Models
Excerpt:
A tumor xenograft model derived from the NCI-N87 human gastric tumor cell line, which shows low expression of 5T4 [5T4+/−; 4,400 binding sites per cell (14)] and high expression of HER2 was also used to evaluate the in vivo efficacy of ASN004….For the two ASN004 dose groups, the complete regressions were sustained with all animals showing complete regressions at the end of the study...
DOI:
https://doi.org/10.1158/1535-7163.MCT-20-0565
