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Association details:
| Biomarker: | TPBG overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | ASN004 (Microtubule inhibitor, 5T4-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ASN004, A 5T4-targeting scFv-Fc Antibody–Drug Conjugate with High Drug-to-Antibody Ratio, Induces Complete and Durable Tumor Regressions in Preclinical Models
Excerpt:
ASN004 was studied in a tumor xenograft model derived from the A431 (human cervical epidermoid, 5T4+; 88,000 binding sites per cell) tumor cell line….Complete tumor growth regression was observed for three ASN004 dose groups...Similar results were obtained for a xenograft model derived from the high 5T4-expressing MDA-MB-231-5T4OE (transfectant, human breast carcinoma, 5T4+++; 16,000,000 binding sites per cell) cell line (Fig. 3B).
DOI:
https://doi.org/10.1158/1535-7163.MCT-20-0565
