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Association details:
| Biomarker: | TPBG expression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | ALG.APV-527 (CD137 agonist, 5T4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
796 ALG.APV-527: a 5T4 tumor directed bispecific approach utilizing ADAPTIRTM technology designed for conditional 4-1BB T cell/NK agonism against solid tumors
Published date:
11/09/2021
Excerpt:
Additionally, ALG.APV-527 enhanced primary immune cell-mediated killing of 5T4-expressing tumor cells...ALG. APV-527 is designed to elicit safe and efficacious 4-1BB-mediated antitumor activity in a range of 5T4-expressing tumor indications....ALG.APV-527 is a promising anti-cancer therapeutic for the treatment of a variety of 5T4-expressing solid tumors.
