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Association details:
Biomarker:TP53 W146*
Cancer:Lung Adenocarcinoma
Drug:Xalkori (crizotinib) (ALK inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
Source:
Title:

Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition

Published date:
08/03/2020
Excerpt:
Targeted next-generation sequencing (NGS) of 39 cancer-associated genes [SNaPshot NGS version 1; Massachusetts General Hospital (MGH), Boston, MA] detected the presence of a G2032R (c.6094G > A) mutation in the ROS1 kinase domain10. Additionally, two single-nucleotide variants were detected in TP53: W146* (c.437G > A) and N263D (c.787A > G). The latter, TP53 N263D variant (rs72661119), has been reported in 10 of 13,894 individuals in the South Asian population and is likely a polymorphism30. The patient was treated with stereotactic body radiation therapy (SBRT) to the growing lung nodule and continued on crizotinib. Subsequent scans showed growth of an adjacent left lower lobe lung nodule, which was not biopsied, but treated with microwave ablation (Fig. 1a).
DOI:
https://doi.org/10.1038/s41698-020-0127-9