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Association details:
| Biomarker: | TP53 R273H |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | prexasertib (ACR-368) (Chk2 inhibitor, Chk1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
EGFR signaling promotes resistance to CHK1 inhibitor prexasertib in triple negative breast cancer
Published date:
12/05/2020
Excerpt:
Prexasertib effectively induced cell death at nanomolar concentrations for most TNBC cell lines, including BRCA mutated HCC1937 and MX-1...The highest sensitivity to prexasertib was observed in MX-1 cells (orange line, IC50, 5.7 nmol/L), while MDA-468 cells were highly resistant (blue line, IC50, 105 nmol/L).
DOI:
10.20517/cdr.2020.73
