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Association details:
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
Title:

Emergence of High Level of MET Amplification as Off-Target Resistance to Selpercatinib Treatment in KIF5B-RET NSCLC

Published date:
07/01/2020
Excerpt:
Evidence of disease progression with a new adrenal lesion was seen on a subsequent scan 7.5 months after the selpercatinib treatment...Concurrently, plasma genotyping revealed the re-emergence of KIF5B-RET and RET-RPP38 at an AF of 4.59% and 2.30%, respectively. The original TP53 P190T was again detected at an AF of 12.2%. A high level of MET amplification (copy number ∼17), not previously present, was identified from plasma genotyping at the time of progression ( Fig. 2)...Given her symptomatic recurrence, no tumor re-biopsy was performed at the time of selpercatinib progression.
DOI:
10.1016/j.jtho.2020.03.020