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Association details:
Biomarker:
TP53 mutation
Cancer:
Small Lymphocytic Lymphoma
Drug:
Keytruda (pembrolizumab)
(
PD1 inhibitor
) +
Imbruvica (ibrutinib)
(
BTK inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: A2 - Guideline
Source:
NCCN
Published date:
12/03/2020
Excerpt:
Nivolumab and pembrolizumab ± ibrutinib are included as options with a category 2B recommendation for patients unable to receive chemoimmunotherapy, patients with del (17p) or TP53 mutation, or those with chemoimmunotherapy-refractory disease.
Evidence Level:
Sensitive: C2 – Inclusion Criteria
New
Source:
clinicaltrials.gov
Title:
Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Excerpt:
...TP53 mutations, SF3B1 mutations, or NOTCH1 mutation....
Trial ID:
NCT03204188
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