^
Association details:
Evidence:
Evidence Level:
Sensitive: A2 - Guideline
New
Source:
Excerpt:
CLL/SLL with del(17p)/TP53 mutation: Relapsed/refractory therapy...Preferred regimens…Duvelisib
Evidence Level:
Sensitive: B - Late Trials
Source:
Title:

The phase 3 DUO trial: duvelisib vs ofatumumab in relapsed and refractory CLL/SLL

Published date:
12/06/2018
Excerpt:
We report here the results of DUO, a global phase 3 randomized study of duvelisib vs ofatumumab monotherapy for patients with relapsed or refractory (RR) CLL/SLL….The study met the primary study end point by significantly improving progression-free survival per independent review committee assessment compared with ofatumumab for all patients (median, 13.3 months vs 9.9 months; hazard ratio [HR] = 0.52; P < .0001), including those with high-risk chromosome 17p13.1 deletions [del(17p)] and/or TP53 mutations (HR = 0.40; P = .0002).
DOI:
10.1182/blood-2018-05-850461
Trial ID: