^
Association details:
| Biomarker: | TP53 mutation |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | Nutlin-3 (MDM2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues
Excerpt:
No significant differences in cell viability was observed in TP53 mutated versus wild type samples for purine analogues, but TP53 mutated MCL cells showed resistance for the MDM2 inhibitor nutlin-3a…TP53 mutations confer resistance to nutlin-3a…
DOI:
https://doi.org/10.1016/j.leukres.2021.106608
