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Association details:
| Biomarker: | TP53 mutation |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | adavosertib (AZD1775) (WEE1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring
Published date:
09/18/2021
Excerpt:
Patients with newly diagnosed mCRC were registered into FOCUS4 and tested for TP53 and RAS mutations...An exploratory analysis showed that adavosertib had the most PFS effect in patients with KRAS codons 12/13/TP53-mutant tumors...
DOI:
10.1200/JCO.21.01435
