We therefore correlated TP53 mutational status with immune landscapes and with complete responses to flotetuzumab in a cohort of 45 patients with R/R AML, including 15 patients with TP53 mutations and/or chromosome 17p deletions...Overall response rate (ORR: CR, CRi, MLFS, or partial response) in patients with TP53 mutations and/or 17p abnormalities was 60% (9/15), with 47% (7/15) achieving complete response (<5% BM blasts on study; Figure 6B).