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Association details:
| Biomarker: | TP53 expression |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | ENMD-2076 (Aurora kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models
Excerpt:
Within the triple-negative breast cancer subset, cell lines with a p53 mutation and increased p53 expression were more sensitive to the cytotoxic and proapoptotic effects of ENMD-2076 exposure than cell lines with decreased p53 expression.
DOI:
10.1158/1078-0432.CCR-12-1611
