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Association details:
| Biomarker: | TP53 expression |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | sunitinib (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
MP18-18: P53 is involved in resistance to sunitinib in renal cell carcinoma
Published date:
05/15/2020
Excerpt:
Additionally, we investigated the expression of P53 in 52 ccRCC cases treated with sunitinib treatment. A Kaplan-Meier analysis showed that the positive cases of P53 were associated with poor prognosis after sunitinib treatment (P = 0.04)
Source:
Title:
MP18-18: P53 is involved in resistance to sunitinib in renal cell carcinoma
Published date:
05/15/2020
Excerpt:
...the expression of P53 was decreased in sunitinib resistant cells compared with that in parental cells...The expression of P53 was downregulated in sunitinib resistant RCC cell lines.
