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Association details:
| Biomarker: | TOP2A overexpression |
|---|---|
| Cancer: | Adrenal Cortex Carcinoma |
| Drug: | aclarubicin (DNA intercalator) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
TOP2A is overexpressed in and a therapeutic target for adrenocortical carcinoma
Excerpt:
...TOP2A mRNA expression was significantly higher in ACC than in benign and normal adrenocortical tissue samples (p < 0.001)…Aclarubicin, TOP2A inhibitor, had potent antiproliferative activity out of 11 active TOP2 inhibitors, which significantly decreased proliferation and tumor spheroid size in ACC cell lines (p< 0.05)...
DOI:
10.1530/ERC-12-0403
