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Association details:
| Biomarker: | TNIK overexpression |
|---|---|
| Cancer: | Lung Non-Small Cell Squamous Cancer |
| Drug: | NCB-0846 (Wnt signalling pathway inhibitor, TNIK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2818 / 9 - Investigating TNIK as a radiosensitizing target in lung squamous cell carcinoma
Published date:
03/15/2023
Excerpt:
We observed that pretreatment with NCB-0846 significantly potentiated the efficacy of IR in eradicating TNIKhigh LK2 tumors but not TNIKlow KNS62 tumors. Overall, these results indicate that TNIK inhibition may be a viable strategy to enhance the efficacy of radiotherapy in LSCC tumors with high TNIK expression.
