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Association details:
Biomarker:TNFRSF8 positive
Cancer:Hodgkin Lymphoma
Drug Class:CD30-targeted CAR-T immunotherapy
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

CAR T-Cell Therapy in Hodgkin Lymphoma

Published date:
09/21/2022
Excerpt:
To assess the safety and activity of banked CD30 CAR EBVSTs, we are treating patients with multiply relapsed or refractory CD30-positive lymphomas in a phase 1 dose escalation study….We have treated 9 patients so far, all with Hodgkin lymphoma. Of these, 2 had an initial response to treatment....5 patients have had a complete response and 4 have had a partial response (overall response rate of 82%), with higher dose levels being associated with better responses...CD30.CAR EBVSTs can safely be given to allogeneic recipients and may cause significant tumor responses including complete remissions.