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Association details:
| Biomarker: | TNFRSF10B overexpression |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | Oba01 (Microtubule inhibitor, DR5-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer
Published date:
04/29/2023
Excerpt:
Our data revealed that DR5 was highly expressed on the plasma membrane of PC cells and Oba01 showed potent in vitro antitumor activity in a panel of human DR5-positive PC cell lines.
DOI:
https://doi.org/10.1038/s41419-023-05820-1
