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Association details:
| Biomarker: | TMB-L |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | Focus V (anlotinib) (Multi-tyrosine kinase inhibitor) + benmelstobart (APL-502) (PD-L1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer
Published date:
11/17/2023
Excerpt:
Patients with both low MSAF and low bTMB showed a notably better objective response to anlotinib plus TQB2450 (70% vs. 11%, P < 0.001) and a significantly longer median PFS (11.0 vs. 2.9 months, P < 0.001) than patients with other scenarios….To the best of our knowledge, this is the first investigation that establishes bTMB and MSAF as biomarkers associated with treatment response and survival outcomes of pretreated aTNBC patients receiving combined immunotherapy and antiangiogenic therapy.
DOI:
10.1038/s41392-023-01672-5
Trial ID:
