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Association details:
| Biomarker: | TMB-L |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Avastin (bevacizumab) (VEGF-A inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Exploratory analysis of baseline tumor burden in the TRUSTY study: A randomized phase 2/3 study of trifluridine/tipiracil plus bevacizumab versus irinotecan and fluoropyrimidine plus bevacizumab as second-line treatment in patients with metastatic colorectal cancer.
Published date:
01/18/2022
Excerpt:
In pts with STL < 60 mm, FTD/TPI plus BEV was comparably effective to the control: median OS was 21.4 versus 20.7 months (HR: 0.92; 95% CI: 0.55-1.55), median PFS was 5.6 versus 6.0 months (HR: 1.23; 95% CI: 0.87-1.72)...FTD/TPI + BEV might be a second-line treatment option for mCRC pts with low tumor burden (STL < 60 mm).
Secondary therapy:
trifluridine/tipiracil
