...we conducted B-F1RST (NCT02848651), an open-label, phase 2 trial that evaluated bTMB as a predictive biomarker for first-line atezolizumab monotherapy in locally advanced or metastatic stage IIIB–IVB non-small cell lung cancer (n = 152)....Median OS was 23.9 months in the bTMB ≥ 16 group versus 13.4 months in the bTMB < 16 group (HR = 0.66, 90% CI: 0.40, 1.10, P = 0.18; Fig. 2b)….In a secondary biomarker analysis, ORR in the bTMB ≥ 16 versus bTMB < 16 subgroups was 35.7% (95% CI: 19.2, 55.5) versus 5.5% (95% CI: 2.2, 12.2) (P < 0.0001). ORR (95% CI) in the bTMB ≥ 10 versus bTMB < 10 groups was 20.4% (10.5, 33.7) versus 7.1% (2.9, 15.3). ORR (95% CI) for bTMB:≥ 20 versus bTMB < 20 was 47.4% (25.2, 69.1) versus 6.0% (2.6, 12.2).