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Association details:
| Biomarker: | TMB-H |
|---|---|
| Cancer: | Esophageal Cancer |
| Drug: | Yutuo (zimberelimab) (PD1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Dose escalation and expansion (phase Ia/Ib) study of GLS-010, a recombinant fully human antiprogrammed death-1 monoclonal antibody for advanced solid tumors or lymphoma
Published date:
03/07/2021
Excerpt:
...patients (n = 18) came from the gastric cancer and esophageal cancer cohorts. Results showed that high b-TMB patients have better ORR (40.0% Versus. 16.1%, p = 0.010) than those with a low b-TMB level. The high b-TMB level patients had potentially longer PFS (p = 0.038) but similar OS...high b-TMB level has the potential for identifying patients responding to GLS-010...
DOI:
https://doi.org/10.1016/j.ejca.2021.01.020
Trial ID:
