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    Association details:
    Biomarker:TMB-H + KDM6A mutation
    Cancer:Urothelial Cancer
    Drug Class:Immunotherapy
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    New
    Source:
    ASCO-GU 2023
    Title:

    Association of biomarkers and response to immune checkpoint inhibitors (ICIs) in patients with metastatic urothelial carcinoma (mUC) with high and low tumor mutation burden (TMB).

    Published date:
    02/13/2023
    Excerpt:
    In TMB high pts, presence of DDR, MLL2, KDM6A, PIK3CA and TERTp alterations were each associated with improved outcomes, while presence of CDKN2B alterations was associated with inferior outcomes (Table).
    DOI:
    10.1200/JCO.2023.41.6_suppl.534