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Association details:
| Biomarker: | TLR3 overexpression |
|---|---|
| Cancer: | Clear Cell Renal Cell Carcinoma |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
168 Associations of high toll-like receptor 3 gene expression and favorable anti-tumor immune microenvironment in metastatic clear cell renal cell carcinoma treated with immune checkpoint inhibitors
Published date:
11/04/2023
Excerpt:
Among the 25 patients who met the inclusion criteria, the major response rate was 50% for 6 patients with high TLR3 gene expression (>75th percentile)...High intratumoral TLR3 gene expression was associated with a higher rate of major responses in ccRCC patients treated with immune checkpoint inhibitors (ICIs).
DOI:
10.1136/jitc-2023-SITC2023.0168
