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Association details:
| Biomarker: | TIMP2 rs7501477 |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Regimen: | DCF (5-fluorouracil + cisplatin + docetaxel) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Germline Variants in Angiogenesis-Related Genes Contribute to Clinical Outcome in Head and Neck Squamous Cell Carcinoma
Published date:
04/06/2022
Excerpt:
Hence, we assessed the relationship between FGF/FGFR, PDGF/PDGFR, MMP, and TIMP genetic variants and treatment outcomes in HNSCC patients receiving radiotherapy (RT) alone or combined with cisplatin-based chemotherapy....The MMP2 rs7201 C and TIMP2 rs7501477 T were associated with a risk of locoregional failure in the entire cohort (p = 0.032 and 0.045, respectively).
DOI:
10.3390/cancers14071844
