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Association details:
| Biomarker: | TIMP2 overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | 5-fluorouracil (Thymidylate synthase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
TIMP-2 as a predictive biomarker in 5-Fu-resistant colorectal cancer
Published date:
03/11/2023
Excerpt:
...the patient-derived xenograft (PDX) model of 5-Fu resistance was used to evaluate the feasibility of TIMP-2 as a predictive biomarker of 5-Fu resistance….Our experimental results display that TIMP-2 expression is elevated in colorectal cancer drug-resistant cell lines, and its expression level is closely related to 5-Fu resistance.
DOI:
10.1007/s00432-023-04670-w
