^
    Back
    Association details:
    Biomarker:TIAM1 overexpression
    Cancer:Breast Cancer
    Drug:dactolisib (RTB101) (mTOR inhibitor, PI3K inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Biochem Genet
    Title:

    TIAM1 Upregulation Confers NVP-BEZ235 Resistance to Breast Cancer Cells Through FGFR/STAT3 Pathway

    Published date:
    07/15/2020
    Excerpt:
    ...while TIAM1 overexpression increased the IC50 of NVP-BEZ235 of breast cancer cells, which suggested that TIAM1 was one of the contributors for NVP-BEZ235 resistance.
    DOI:
    10.1007/s10528-020-09982-x