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Association details:
| Biomarker: | TGM2 overexpression |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | MD102 (TGM2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
5445 - New discovery and development of transglutaminase 2 inhibitor
Published date:
03/09/2022
Excerpt:
The IC50 value of TGase2 activity inhibition of MD102 is 100-400 nM similar to positive control of streptonigrin and IC50 of cell growth inhibition was 1~10 μM in TGase2 overexpressing RCC, TNBC and gastric cancer cell lines...MD102, a TGase2 inhibitor, is expected to be a potential candidate in TGase2-overexpressing cancers, including RCC and TNBC, as it shows antitumor activity without serious toxicity...
