The IC50 value of TGase2 activity inhibition of MD102 is 100-400 nM similar to positive control of streptonigrin and IC50 of cell growth inhibition was 1~10 μM in TGase2 overexpressing RCC, TNBC and gastric cancer cell lines...MD102, a TGase2 inhibitor, is expected to be a potential candidate in TGase2-overexpressing cancers, including RCC and TNBC, as it shows antitumor activity without serious toxicity...