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Association details:
| Biomarker: | TFF1 overexpression + ER positive |
|---|---|
| Cancer: | HER2 Negative Breast Cancer |
| Drug Class: | CDK4 inhibitor + CDK6 inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
4346 / 21 - TFF1 and TFF3 predict response to CDK4/6 inhibitors in breast cancer patients
Published date:
03/15/2023
Excerpt:
In addition, IHC analysis of TFF1 and TFF3 expressions in 73 pre-treated BC patient samples showed significantly higher protein expression levels in late progressors than in early progressors....Our results identified and validated the common biomarkers, TFF1 and TFF3, as predictors of CDK4/6i response efficacy in ER-positive, HER2-negative BC patients.
