^
Association details:
| Biomarker: | TET3 rs7560688 |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Avastin (bevacizumab) (VEGF-A inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Impact of polymorphisms within genes involved in regulating DNA methylation in metastatic colorectal cancer patients enrolled in three independent, randomized, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC, and FIRE-3
Excerpt:
A total of 884 mCRC patients from six treatment arms of three independent phase III trials....TET3 rs7560688 was associated with TR (OR = 1.44, 95% CI 1.10 – 1.89, P = 0.009, FDR adjusted P=0.062). D. IDH1 rs1437410 was suggestively associated with PFS (HR = 1.15, 95% CI 1.01 – 1.31, P = 0.034, FDR adjusted P=0.14).
Secondary therapy:
FOLFIRI; FOLFOXIRI; FOLFOX
DOI:
10.1016/j.ejca.2019.01.105