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Association details:
Biomarker:TET1 mutation
Cancer:Melanoma
Drug Class:Immunotherapy
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers

Published date:
10/17/2019
Excerpt:
…discovery cohort, which included 519 patients across five cancer types: bladder cancer (n = 27), esophagogastric cancer (n = 40), head and neck squamous cell carcinoma (HNSCC) (n = 10), melanoma (n = 148), and NSCLC (n = 294)….TET1-MUT was significantly enriched in patients responding to ICI treatment (Fig ​(Fig2a)2a) (P = 0.003), indicating that TET1-MUT may be a potential predictive biomarker for ICI treatment.
DOI:
10.1186/s40425-019-0737-3