^
Association details:
| Biomarker: | TERT overexpression |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | U0126 (MEK1 inhibitor, MEK2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Inhibition of hTERT expression by MAP kinase inhibitor induces cell death in renal cell carcinoma
Excerpt:
Significantly diminished ERK phosphorylation and hTERT mRNA expression concomitantly reduced telomerase activity that was observed after U0126 treatment. Subsequently, cell viability and migration were significantly inhibited after treatment with U0126 in both the cell lines to that of control (P = 0.001). In addition, U0126-treated cells showed significantly increased apoptosis (P = 0.001) to that of controls.
DOI:
10.1016/j.urolonc.2017.01.019
