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Association details:
| Biomarker: | TERT mutation + MGMT promoter methylation |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | temozolomide (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
360O - Telomerase reverse transcriptase (TERT) promoter mutation and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation-mediated sensitivity to temozolomide in IDH-wildtype glioblastoma: Is there a link?
Published date:
09/20/2020
Excerpt:
TERT promoter mutations were not associated with improved outcome in patients with MGMT promoter-methylated tumors….Analysis of two independent cohorts of glioblastoma patients, including the prospective GGN cohort, did not confirm previous data suggesting that TERT promoter mutations confer an enhanced benefit from TMZ in patients with MGMT promoter-methylated glioblastoma.
