PFS was significantly worse in patients with the following mutations: AMER1 (p=0.0073), DNMT3A (p=0.0075), ETV5 (p=0.012), EWSR1 (p=0.016), FANCA (p=0.019), IKBKE (p=0.0073), NOTCH1 (p=0.015), STAG2 (p=0.012) and TCF7L2 (p=0.0073)….Fruquintinib combined with Sintilimab seemed not resulted in a significant increase in ORR, DCR and OS in refractory mCRC.