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    Association details:
    Biomarker:STK11 F354L
    Cancer:Breast Cancer
    Drug:everolimus (mTOR inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    New
    Source:
    Cold Spring Harb Mol Case Stud
    Title:

    Exceptional durable response to everolimus in a patient with biphenotypic breast cancer harboring an STK11 variant

    Excerpt:
    ...we report a near-complete 14-mo response to everolimus therapy of a heavily pretreated patient with biphenotypic, metastatic breast cancer. Genomic profiling of her metastatic liver specimen identified a single reportable point mutation under loss of heterozygosity (LOH), STK11 F354L.
    DOI:
    10.1101/mcs.a000778