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    Association details:
    Biomarker:STK11 deletion
    Cancer:Non Small Cell Lung Cancer
    Drug:omipalisib (GSK2126458) (mTOR inhibitor, PI3K inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    J Thorac Oncol
    Title:

    The Effect of LKB1 Activity on the Sensitivity to PI3K/mTOR Inhibition in Non-Small Cell Lung Cancer

    Excerpt:
    Similarly, GSK2126458, the dual PI3K and mTORC1/2 inhibitor, showed a significant difference in sensitivity between LKB1 wild-type and LKB1-mutant cell lines (Fig. 2B [p = 0.0105 according to the Wilcoxon rank sum test]).
    DOI:
    10.1016/j.jtho.2019.02.019