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Association details:
Biomarker:
STK11 deletion + TMB-H
Cancer:
Non Small Cell Lung Cancer
Drug Class:
PD-L1 inhibitor
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
AACR 2020
Title:
1016 / 11 - Inhibition of chemokine-induced myeloid cells potentiates the anti-PD-1 response in KRAS/LKB1 mutant non-small cell lung cancer
Published date:
05/27/2020
Excerpt:
Inhibition of G-MDSC enhances the efficacy of anti-PD-1 blockade in LKB1-deficient tumors bearing a high TMB.
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