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    Association details:
    Biomarker:STK11 D194E
    Cancer:Pancreatic Cancer
    Drug:everolimus (mTOR inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    New
    Source:
    J Clin Oncol
    Title:

    mTOR Inhibitor Treatment of Pancreatic Cancer in a Patient With Peutz-Jeghers Syndrome

    Excerpt:
    Leukocyte DNA sequencing of the STK11/LKB1 gene showed a PJS-defining mutation c.582C>A, which led to the amino acid substitution p.Asp194Glu, D194E….With everolimus treatment, our patient with PJS experienced a partial response of an acinar cell carcinoma of the pancreas and concomitant clearance of large colon polyps.
    DOI:
    10.1200/JCO.2010.32.7825